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Genetic association and computational analysis of MTHFR gene polymorphisms rs1801131 and rs1801133 with breast cancer in the Bangladeshi population.

Scientific reports - 16 Oct 2024

Alam Nazia Fairooz, Ahmed Rubaiat, Mahmud Zimam, Tamanna Sonia, Shaon Md Akeruzzaman, Howlader Md Zakir Hossain

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) plays a crucial role in regulating one-carbon metabolism. Polymorphisms within the MTHFR gene have been found to increase the risk of breast cancer in different populations. In this study, we evaluated the association of polymorphisms of the MTHFR gene (rs1801133 and rs1801131) with the risk of breast cancer in the Bangladeshi population. This case‒control study...

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Identifiers

PMID: 39414907
DOI: 10.1038/s41598-024-75656-y
PMCID: PMC11484754

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