Article
Aldo-keto reductase family 1 member C3 (AKR1C3) gene polymorphism (rs12529) is associated with breast cancer in Bangladeshi population: A case-control study and computational investigation.
PloS one - 1 Jan 2025
Shaon Md Akeruzzaman, Ansari Farzana, Mahmud Zimam, Tamanna Sonia, Ibrahim Md Nazid Bin, Alam Nazia Fairooz, Hossain Md Naiem, Howlader Md Zakir Hossain
Abstract excerpt
Breast cancer is defined as the unchecked growth of breast cells, with imbalances in prostaglandin and steroid hormone metabolism contributing to disease risk by altering prostaglandin types and forms (strong and weak) of steroid hormones. The AKR1C3 enzyme plays a key role in managing these metabolic processes. This study investigated the association between the AKR1C3 gene polymorphism (rs12529) and the risk of...
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