Article
Unraveling the molecular significance of CYP1A2 (rs762551; c.-9-154 C>A) genetic variant on breast carcinoma susceptibility: Insights from case-control study and meta-analysis.
Pathology, research and practice - 1 Sept 2024
Alalawy Adel I, Sakran Mohamed I, Alzuaibr Fahad M, Alotaibi Maeidh A, Elshazli Rami M
Abstract excerpt
BACKGROUND: The human cytochrome P450 (CYP) superfamily encompasses different categories of isoenzymes that contribute to multiple metabolic processes involving drug detoxification, cellular signaling, and the proliferation of malignant tissues. Using genetic technology, customized bioinformatic analysis, and meta-analysis design, the main goal of this study was to identify the association between the...
Topics
- Female
- Humans
- Breast Neoplasms
- Case-Control Studies
- Cytochrome P-450 CYP1A2
- Genetic Predisposition to Disease
- Polymorphism, Single Nucleotide