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Article

Synonymous Variants: Necessary Nuance in Our Understanding of Cancer Drivers and Treatment Outcomes.

Journal of the National Cancer Institute - 8 Aug 2022

Kaissarian Nayiri M, Meyer Douglas, Kimchi-Sarfaty Chava

Abstract excerpt

Once called "silent mutations" and assumed to have no effect on protein structure and function, synonymous variants are now recognized to be drivers for some cancers. There have been significant advances in our understanding of the numerous mechanisms by which synonymous single nucleotide variants (sSNVs) can affect protein structure and function by affecting pre-mRNA splicing, mRNA expression, stability,...

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PMID: 35477782
DOI: 10.1093/jnci/djac090
PMCID: PMC9360466

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