Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Coagulation factor XIII: An unrecognized regulator of fibrinolytic phenotypes in trauma-A potential link to cysteine cathepsin degradation of plasminogen.

The journal of trauma and acute care surgery - 1 Feb 2026

Moore Peter K, Moore Ernest E, Garner Raleigh, Hansen Kirk, Barrett Christopher D, Sauaia Angela, Chandler James, Janssen William J, Moore Hunter B

Abstract excerpt

BACKGROUND: Trauma-induced coagulopathy (TIC) has distinct fibrinolytic phenotypes based on viscoelastic testing. The underlying mechanisms behind differences in fibrinolytic responses to trauma are unclear. We hypothesized that plasma proteins crosslinked into fibrin clots by the transglutaminase activity of factor XIII (FXIII) may explain tissue-type plasminogen activator (tPA) responsiveness observed in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Coagulation Disorders
Share to Cathepsins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cysteine

Share to Factor XIII

Share to Fibrinolysis

Share to Plasminogen

Share to Tissue Plasminogen Activator

Share to Wounds and Injuries

Source

Identifiers

PMID: 40712062
DOI: 10.1097/TA.0000000000004706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Coagulation factor XIII: An unrecognized regulator of fibrinolytic phenotypes in trauma-A potential link to cysteine cathepsin degradation of plasminogen.PMID 40712062Read ↗

Fibrinolysis shutdown is associated with a fivefold increase in mortality in trauma patients lacking hypersensitivity to tissue plasminogen activator.Semantic proximity Read ↗

A Novel Fibrinolysis Resistance Capacity Assay can Detect Fibrinolytic Phenotypes in Trauma Patients.Semantic proximity Read ↗

Differentiating Pathologic from Physiologic Fibrinolysis: Not as Simple as Conventional Thrombelastography.Semantic proximity Read ↗

Harmful or Physiologic: Diagnosing Fibrinolysis Shutdown in a Trauma Cohort With Rotational Thromboelastometry.Semantic proximity Read ↗

Injury Severity is a Key Contributor to Coagulation Dysregulation and Fibrinogen ConsumptionSemantic proximity Read ↗

Early hemostatic responses to trauma identified with hierarchical clustering analysis.Semantic proximity Read ↗

Regulation of fibrinolysis by thrombin activatable fibrinolysis inhibitor, an unstable carboxypeptidase B that unites the pathways of coagulation and fibrinolysis.Semantic proximity Read ↗

Characterizing the impact of traumatic brain injury phenotype on coagulation dynamics in severely injured patients.Semantic proximity Read ↗

The Plasma Contact System 2.0Semantic proximity Read ↗

Differentiating disseminated intravascular coagulation (DIC) with the fibrinolytic phenotype from coagulopathy of trauma and acute coagulopathy of trauma-shock (COT/ACOTS).Semantic proximity Read ↗

Variations in clot phenotype following injury: The MA-R ratio and fragile clots.Semantic proximity Read ↗

Factor XIII and Fibrin Clot Properties in Acute Venous Thromboembolism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.