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Article

Characterizing the impact of traumatic brain injury phenotype on coagulation dynamics in severely injured patients.

Thrombosis research - 1 Feb 2026

Gosselin Andrew R, Ahmad Sameer, Hanna Joseph S, Goswami Julie, Tutwiler Valerie

Abstract excerpt

BACKGROUND: In severely injured patients, altered coagulation impairs stable clot formation and increases mortality. Traumatic brain injury (TBI) precipitates alterations in clot formation and breakdown. In this study, we aimed to characterize clotting kinetics, mechanics, fibrin networks, and circulating proteomic markers in TBI patients, and correlate these biomarkers to outcomes. METHODS: Plasma samples were...

Topics

Humans
Brain Injuries, Traumatic
Female
Male
Adult
Blood Coagulation
Middle Aged
Phenotype
Fibrinolysis
Biomarkers
Aged
Thrombin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41576751
DOI: 10.1016/j.thromres.2026.109583
PMCID: PMC13094749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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