Article
Fibrinolysis shutdown is associated with a fivefold increase in mortality in trauma patients lacking hypersensitivity to tissue plasminogen activator.
The journal of trauma and acute care surgery - 1 Dec 2017
Moore Hunter B, Moore Ernest E, Huebner Benjamin R, Dzieciatkowska Monika, Stettler Gregory R, Nunns Geoffrey R, Lawson Peter J, Ghasabyan Arsen, Chandler James, Banerjee Anirban, Silliman Christopher, Sauaia Angela, Hansen Kirk C
Abstract excerpt
BACKGROUND: Fibrinolysis shutdown (SD) is an independent risk factor for increased mortality in trauma. High levels of plasminogen activator inhibitor-1 (PAI-1) directly binding tissue plasminogen activator (t-PA) is a proposed mechanism for SD; however, patients with low PAI-1 levels present to the hospital with a rapid TEG (r-TEG) LY30 suggestive SD. We therefore hypothesized that two distinct phenotypes of SD...
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