Article
African ancestry GWAS of dementia in a large military cohort identifies significant risk loci.
Molecular psychiatry - 1 Mar 2023
Sherva Richard, Zhang Rui, Sahelijo Nathan, Jun Gyungah, Anglin Tori, Chanfreau Catherine, Cho Kelly, Fonda Jennifer R, Gaziano J Michael, Harrington Kelly M, Ho Yuk-Lam, Kremen William S, Litkowski Elizabeth, Lynch Julie, Neale Zoe, Roussos Panos, Marra David, Mez Jesse, Miller Mark W, Salat David H, Tsuang Debby, Wolf Erika, Zeng Qing, Panizzon Matthew S, Merritt Victoria C, Farrer Lindsay A, Hauger Richard L, Logue Mark W
Abstract excerpt
While genome wide association studies (GWASs) of Alzheimer's Disease (AD) in European (EUR) ancestry cohorts have identified approximately 83 potentially independent AD risk loci, progress in non-European populations has lagged. In this study, data from the Million Veteran Program (MVP), a biobank which includes genetic data from more than 650,000 US Veteran participants, was used to examine dementia genetics in...
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