Article
TERT promoter mutations and gene amplification in endometrial cancer.
Gynecologic oncology - 1 Dec 2023
Praiss Aaron M, Marra Antonio, Zhou Qin, Rios-Doria Eric, Momeni-Boroujeni Amir, Iasonos Alexia, Selenica Pier, Brown David N, Aghajanian Carol, Abu-Rustum Nadeem R, Ellenson Lora H, Weigelt Britta
Abstract excerpt
OBJECTIVE: To assess the clinicopathologic, molecular profiles, and survival outcomes of patients with endometrial carcinomas (ECs) harboring telomerase reverse transcriptase (TERT) hotspot mutations or gene amplification. METHODS: ECs harboring somatic TERT promoter hotspot mutations or gene amplification (TERT-altered) were identified from 1944 ECs that underwent clinical tumor-normal sequencing from...
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