Gene-environment interactions modulate the phenotype severity in mouse models of congenital craniofacial syndromes.

Abstract excerpt

Birth defects are the leading cause of infant mortality, and most inborn errors of development are multifactorial in origin resulting from complex gene-environment interactions. Definition of specific gene-environment interactions in the etiology and pathogenesis of congenital disorders is critically needed in the absence of genotype-phenotype correlation but is challenging. This is particularly true for...

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