<i>Tcof1</i> /Treacle is required for neural crest cell formation and proliferation deficiencies that cause craniofacial abnormalities

Abstract excerpt

Neural crest cells are a migratory cell population that give rise to the majority of the cartilage, bone, connective tissue, and sensory ganglia in the head. Abnormalities in the formation, proliferation, migration, and differentiation phases of the neural crest cell life cycle can lead to craniofacial malformations, which constitute one-third of all congenital birth defects. Treacher Collins syndrome (TCS) is...

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