Article
Effects of thyroxine exposure on the Twist 1 +/- phenotype: A test of gene-environment interaction modeling for craniosynostosis.
Birth defects research. Part A, Clinical and molecular teratology - 1 Oct 2016
Durham Emily L, Howie R Nicole, Black Laurel, Bennfors Grace, Parsons Trish E, Elsalanty Mohammed, Yu Jack C, Weinberg Seth M, Cray James J
Abstract excerpt
BACKGROUND: Craniosynostosis, the premature fusion of one or more of the cranial sutures, is estimated to occur in 1:1800 to 2500 births. Genetic murine models of craniosynostosis exist, but often imperfectly model human patients. Case, cohort, and surveillance studies have identified excess thyroid hormone as an agent that can either cause or exacerbate human cases of craniosynostosis. METHODS: Here we...
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