Article

Peptidome Surveillance Across Evolving SARS-CoV-2 Lineages Reveals HLA Binding Conservation in Nucleocapsid Among Variants With Most Potential for T-Cell Epitope Loss In Spike

2022-03-20

Abstract excerpt

To provide a unique global view of the relative potential for evasion of CD8+ and CD4+ T cells by SARS-CoV-2 lineages as they evolve over time, we performed a comprehensive analysis of predicted HLA-I and HLA-II binding peptides in spike (S) and nucleocapsid (N) protein sequences of all available SARS-CoV-2 genomes as provided by NIH NCBI at a bi-monthly interval between March and December of 2021. A data suppleme...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ab34218c-7808-5e6c-b0c6-10d7fe970771
DOI: 10.1101/2022.03.18.484954

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Peptidome Surveillance Across Evolving SARS-CoV-2 Lineages Reveals HLA Binding Conservation in Nucleocapsid Among Variants With Most Potential for T-Cell Epitope Loss In SpikeDOI 10.1101/2022.03.18.484954Read

The mutational landscape of SARS-CoV-2 variants diversifies T cell targets in an HLA-supertype-dependent manner.Semantic proximity Read

The T cell epitope landscape of SARS-CoV-2 variants of concernSemantic proximity Read

Evolutionary trajectory of SARS-CoV-2 genome shifts during widespread vaccination and emergence of Omicron variantSemantic proximity Read

SARS-CoV-2 Omicron (BA.1 and BA.2) specific novel CD8+ and CD4+ T cell epitopes targeting spike proteinSemantic proximity Read

Bioinformatic analysis of B and T cell epitopes from SARS-CoV-2 Spike, Membrane and Nucleocapsid proteins as a strategy to assess possible cross-reactivity between emerging variants, including Omicron, and other human coronavirusesSemantic proximity Read

Computational assessment of the spike protein antigenicity reveals diversity in B cell epitopes but stability in T cell epitopes across SARS-CoV-2 variantsSemantic proximity Read

The mutational landscape of SARS-CoV-2 variants diversifies T cell targets in an HLA supertype-dependent mannerSemantic proximity Read

Expanding repertoire of SARS-CoV-2 deletion mutations contributes to evolution of highly transmissible variants.Semantic proximity Read

T cell epitope mapping reveals immunodominance of evolutionarily conserved regions within SARS-CoV-2 proteome.Semantic proximity Read

CD8 T cell epitope generation toward the continually mutating SARS-CoV-2 spike protein in genetically diverse human population: Implications for disease control and preventionSemantic proximity Read

ESC - a comprehensive resource for SARS-CoV-2 immune escape variantsSemantic proximity Read

Mutational pressure drives enhanced release of proteasome-generated public CD8<sup>+</sup>T cell epitopes from SARS-CoV-2 RBD of Omicron and its current lineagesSemantic proximity Read