Article
Killer fatigue: Transition to NK-cell-like phenotype is a signature of CAR-T cell exhaustion.
Cell - 9 Dec 2021
Hong Mihe, Chen Yvonne Y
Abstract excerpt
Exhaustion of chimeric antigen receptor (CAR)-T cells hinders their therapeutic efficacy, especially in treating solid tumors. In this issue of Cell, Good et al. develop an in vitro model of antigen-driven CAR-T cell exhaustion to characterize signatures of dysfunction, including a transition to a natural killer (NK)-like phenotype, and suggest new gene targets to prevent exhaustion.
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