Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RAD51C germline mutations in breast and ovarian cancer cases from high-risk families.

PloS one - 1 Jan 2011

Clague Jessica, Wilhoite Greg, Adamson Aaron, Bailis Adam, Weitzel Jeffrey N, Neuhausen Susan L

Abstract excerpt

BRCA1 and BRCA2 are the most well-known breast cancer susceptibility genes. Additional genes involved in DNA repair have been identified as predisposing to breast cancer. One such gene, RAD51C, is essential for homologous recombination repair. Several likely pathogenic RAD51C mutations have been identified in BRCA1- and BRCA2-negative breast and ovarian cancer families. We performed complete sequencing of RAD51C...

Topics

Join the communities discussing this publication.

Aged
BRCA1 Protein
BRCA2 Protein
DNA-Binding Proteins
DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hereditary Breast and Ovarian Cancer Syndrome

Source

Open in PubMed Open full text

Identifiers

PMID: 21980511
DOI: 10.1371/journal.pone.0025632
PMCID: PMC3182241

Genes

BRCA1
BRCA2
XRCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RAD51C germline mutations in breast and ovarian cancer cases from high-risk families.PMID 21980511Read ↗

Identification of six pathogenic RAD51C mutations via mutational screening of 1228 Danish individuals with increased risk of hereditary breast and/or ovarian cancer.Semantic proximity Read ↗

Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patientsSemantic proximity Read ↗

Evaluation of RAD51C as cancer susceptibility gene in a large breast-ovarian cancer patient population referred for genetic testing.Semantic proximity Read ↗

A decade of RAD51C and RAD51D germline variants in cancer.Semantic proximity Read ↗

Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients.Semantic proximity Read ↗

Deleterious RAD51C germline mutations rarely predispose to breast and ovarian cancer in Pakistan.Semantic proximity Read ↗

A decade of RAD51C/D: Germline pathogenic variants and their phenotypic landscapeSemantic proximity Read ↗

Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene.Semantic proximity Read ↗

Mutation screening of RAD51C in high-risk breast and ovarian cancer families.Semantic proximity Read ↗

Germline mutation in the RAD51B gene confers predisposition to breast cancer.Semantic proximity Read ↗

RAD51C germline mutations found in Spanish site-specific breast cancer and breast-ovarian cancer families.Semantic proximity Read ↗

Germline RAD51C mutations in ovarian cancer susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.