Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New insights into genetic comorbidity mechanisms: type 2 diabetes and primary open-angle glaucoma.

BMJ open ophthalmology - 16 Jul 2025

Wang Yixu, Tian Ye, Quan Yumeng, Zhou Shuyan, Dang Yufei, Zhang Xiaoxia, Pei Cheng

Abstract excerpt

AIMS: To investigate the shared genetic mechanisms between type 2 diabetes (T2D) and primary open-angle glaucoma (POAG). Using large-scale genome-wide association study (GWAS) data, we performed single nucleotide polymorphism (SNP) level analysis to detect pleiotropic variants and loci, paired eQTL mapping analysis and gene-level analysis to identify candidate pleiotropic genes. In addition, Mendelian...

Read the complete abstract on PubMed

Topics

Humans
Diabetes Mellitus, Type 2
Glaucoma, Open-Angle
Genome-Wide Association Study
Polymorphism, Single Nucleotide
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Male

Linkage Disequilibrium

Comorbidity

Quantitative Trait Loci

Mendelian Randomization Analysis

Middle Aged

Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 40669929
DOI: 10.1136/bmjophth-2025-002219
PMCID: PMC12273101

Genes

CCND2
HMGA2
ST6GAL1
SVEP1
TCF7L2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New insights into genetic comorbidity mechanisms: type 2 diabetes and primary open-angle glaucoma.PMID 40669929Read ↗

Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes.Semantic proximity Read ↗

Genetic Correlation and Mendelian Randomization Analyses Reveal Causal Links Between Metabolic-Associated Diseases or Risk Factors and Major Eye Diseases.Semantic proximity Read ↗

Genome-wide analysis of genetic pleiotropy and causal genes across three age-related ocular disordersSemantic proximity Read ↗

Mendelian randomization study reveals a population-specific putative causal effect of type 2 diabetes in risk of cataract.Semantic proximity Read ↗

Shared genetic architecture between the two neurodegenerative diseases: Alzheimer’s disease and glaucomaSemantic proximity Read ↗

The vast complexity of primary open angle glaucoma: disease genes, risks, molecular mechanisms and pathobiology.Semantic proximity Read ↗

The putative causal effect of type 2 diabetes in risk of cataract: a Mendelian randomization study in East AsianSemantic proximity Read ↗

A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma and includes a genetic link with Alzheimer’s diseaseSemantic proximity Read ↗

Conventional and Shared Genetic Association Analysis Between Diabetes Mellitus and Sensorineural Hearing Loss.Semantic proximity Read ↗

A Powerful Method for Pleiotropic Analysis under Composite Null Hypothesis Identifies Novel Shared Loci Between Type 2 Diabetes and Prostate CancerSemantic proximity Read ↗

Genome-wide association meta-analysis of 88,250 individuals highlights pleiotropic mechanisms of five ocular diseases in UK Biobank.Semantic proximity Read ↗

Phenotypic and Genetic Links between Body Fat Measurements and Primary Open-Angle Glaucoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.