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Article

Genome-wide association meta-analysis of 88,250 individuals highlights pleiotropic mechanisms of five ocular diseases in UK Biobank.

EBioMedicine - 1 Aug 2022

Xue Zhengbo, Yuan Jian, Chen Fukun, Yao Yinghao, Xing Shilai, Yu Xiangyi, Li Kai, Wang Chenxiao, Bao Jinhua, Qu Jia, Su Jianzhong, Chen Hao

Abstract excerpt

BACKGROUND: Ocular diseases may exhibit common clinical symptoms and epidemiological comorbidity. However, the extent of pleiotropic mechanisms across ocular diseases remains unclear. We aim to examine shared genetic etiology in age-related macular degeneration (AMD), diabetic retinopathy (DR), glaucoma, retinal detachment (RD), and myopia. METHODS: We analyzed genome-wide association analyses for the five ocular...

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Identifiers

PMID: 35841873
DOI: 10.1016/j.ebiom.2022.104161
PMCID: PMC9297108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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