Article
The vast complexity of primary open angle glaucoma: disease genes, risks, molecular mechanisms and pathobiology.
Progress in retinal and eye research - 1 Nov 2013
Janssen Sarah F, Gorgels Theo G M F, Ramdas Wishal D, Klaver Caroline C W, van Duijn Cornelia M, Jansonius Nomdo M, Bergen Arthur A B
Abstract excerpt
Primary open angle glaucoma (POAG) is a complex progressive optic nerve neuropathy triggered by both environmental and genetic risk factors. Several ocular tissues, including the ciliary body, trabecular meshwork and optic nerve head, and perhaps even brain tissues, are involved in a chain of pathological events leading to POAG. Genetic risk evidence for POAG came from family linkage-studies implicating a small...
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