Article
Pedigree models for complex human traits involving the mitochondrial genome.
American journal of human genetics - 1 Dec 1993
Schork N J, Guo S W
Abstract excerpt
Recent biochemical and molecular-genetic discoveries concerning variations in human mtDNA have suggested a role for mtDNA mutations in a number of human traits and disorders. Although the importance of these discoveries cannot be emphasized enough, the complex natures of mitochondrial biogenesis,...
Topics
- Computer Simulation
- DNA Replication
- DNA, Mitochondrial
- Extrachromosomal Inheritance
- Female
- Gene Expression Regulation
- Genes, Lethal
- Humans
- Likelihood Functions
- Male
- Mathematics
- Models, Genetic
- Mothers
- Mutation
- Pedigree