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Article

Association testing of the mitochondrial genome using pedigree data.

Genetic epidemiology - 1 Apr 2013

Liu Chunyu, Dupuis Josée, Larson Martin G, Levy Daniel

Abstract excerpt

In humans, mitochondria contain their own DNA (mtDNA) that is inherited exclusively from the mother. The mitochondrial genome encodes 13 polypeptides that are components of oxidative phosphorylation to produce energy. Any disruption in these genes might interfere with energy production and thus contribute to metabolic derangement. Mitochondria also regulate several important cellular activities including cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23319385
DOI: 10.1002/gepi.21706
PMCID: PMC4171957

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