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Testing the Mother's Curse Hypothesis in Human Mitochondrial Genome Evolution.

Genome biology and evolution - 29 Oct 2025

Yuan Ruiqi, Zhang Jianzhi

Abstract excerpt

In species where mitochondrial DNA (mtDNA) is maternally inherited such as vertebrates, mtDNA mutations harming males only are not subject to purifying selection and thus can spread in a population, especially when these mutations benefit females. Therefore, the mother's curse hypothesis (MCH) posits a greater mtDNA mutation load in males than in females. MCH is potentially important for human health, disease,...

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Identifiers

PMID: 41206013
DOI: 10.1093/gbe/evaf207
PMCID: PMC12629233

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