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Article

IFNG +874 T>A single nucleotide polymorphism is associated with leprosy among Brazilians.

Human genetics - 1 Nov 2010

Cardoso C C, Pereira A C, Brito-de-Souza V N, Dias-Baptista I M, Maniero V C, Venturini J, Vilani-Moreno F R, de Souza F C, Ribeiro-Alves M, Sarno E N, Pacheco A G, Moraes M O

Abstract excerpt

Leprosy is a chronic infectious disease caused by Mycobacterium leprae, a low virulence mycobacterium, and the outcome of disease is dependent on the host genetics for either susceptibility per se or severity. The IFNG gene codes for interferon-γ (IFN-γ), a cytokine that plays a key role in host defense against intracellular pathogens. Indeed, single nucleotide polymorphisms (SNPs) in IFNG have been evaluated in...

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Identifiers

PMID: 20714752
DOI: 10.1007/s00439-010-0872-x

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IFNG

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IFNG +874 T>A single nucleotide polymorphism is associated with leprosy among Brazilians.PMID 20714752Read ↗

Association between the IFNG +874A/T gene polymorphism and leprosy resistance: a meta-analysis.Semantic proximity Read ↗

A single nucleotide polymorphism in the interferon-γ gene (IFNG +874 T/A) is associated with susceptibility to tuberculosisSemantic proximity Read ↗

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The IFNG rs1861494 Single Nucleotide Polymorphism Is Associated with Protection against Tuberculosis Disease in ArgentinaSemantic proximity Read ↗

Association of polymorphism +874 A/T of interferon-γ and susceptibility to the development of tuberculosis: meta-analysis.Semantic proximity Read ↗

Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism.Semantic proximity Read ↗

Functional polymorphism of interferon-γ (IFN-γ) gene +874T/A polymorphism is associated with pulmonary tuberculosis in Zahedan, Southeast Iran.Semantic proximity Read ↗

IFN-γ +875 microsatellite polymorphism as a potential protection marker for leprosy patients from Amazonas state, Brazil.Semantic proximity Read ↗

Single Nucleotide Polymorphisms in IL17A and IL6 Are Associated with Decreased Risk for Pulmonary Tuberculosis in Southern Brazilian Population.Semantic proximity Read ↗

IFNG +874T/A polymorphism and cytokine plasma levels are associated with susceptibility to Mycobacterium tuberculosis infection and clinical manifestation of tuberculosis.Semantic proximity Read ↗

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