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Article

Outlier Detection in Mendelian Randomization.

Statistics in medicine - 1 Jul 2025

Mandl Maximilian M, Boulesteix Anne-Laure, Burgess Stephen, Zuber Verena

Abstract excerpt

Mendelian randomization (MR) uses genetic variants as instrumental variables to infer causal effects of exposures on an outcome. One key assumption of MR is that the genetic variants used as instrumental variables are independent of the outcome conditional on the risk factor and unobserved confounders. Violations of this assumption, that is, the effect of the instrumental variables on the outcome through a path...

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Identifiers

PMID: 40658369
DOI: 10.1002/sim.70143
PMCID: PMC12258383

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