Kv3 channel agonist ameliorates the phenotype of a mouse model of amyotrophic lateral sclerosis.

doi:10.1186/s40478-025-02067-z

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Article

Kv3 channel agonist ameliorates the phenotype of a mouse model of amyotrophic lateral sclerosis.

Acta neuropathologica communications - 14 Jul 2025

Marabita Manuela, Marchioretti Caterina, Aravamudhan Aishwarya, Zito Simona, Falconieri Antonella, Zuccaro Emanuela, Andreotti Roberta, Gambarotto Lisa, Metti Samuele, Tonellato Marika, Adami Valentina, Park Kyung Ho, Gunthorpe Martin J, Large Charles H, Marasco Agostino, Vianello Sara, Rosati Jessica, Belluzzi Elisa, Pozzuoli Assunta, Biz Carlo, Ruggieri Pietro, Basso Manuela, Poletti Angelo, Alvaro Giuseppe, Sorarù Gianni, Bonaldo Paolo, Rossetto Ornella, Pilati Nadia, Pennuto Maria

Abstract excerpt

Voltage-gated potassium channels, Kv3.1, Kv3.2, Kv3.3, and Kv3.4, facilitate rapid repolarization and shape action potentials, which are crucial to maintaining high-frequency firing. Little is known about the expression and function of Kv3 channels in skeletal muscle. We show that these channels are expressed in type IIa/IIx fibers, and their transcript levels progressively increase from postnatal age to...

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PMID: 40653481
DOI: 10.1186/s40478-025-02067-z
PMCID: PMC12257725

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