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Article

Decrease of a Current Mediated by Kv1.3 Channels Causes Striatal Cholinergic Interneuron Hyperexcitability in Experimental Parkinsonism.

Cell reports - 6 Sept 2016

Tubert Cecilia, Taravini Irene R E, Flores-Barrera Eden, Sánchez Gonzalo M, Prost María Alejandra, Avale María Elena, Tseng Kuei Y, Rela Lorena, Murer Mario Gustavo

Abstract excerpt

The mechanism underlying a hypercholinergic state in Parkinson's disease (PD) remains uncertain. Here, we show that disruption of the Kv1 channel-mediated function causes hyperexcitability of striatal cholinergic interneurons in a mouse model of PD. Specifically, our data reveal that Kv1 channels containing Kv1.3 subunits contribute significantly to the orphan potassium current known as IsAHP in striatal...

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Identifiers

PMID: 27568555
DOI: 10.1016/j.celrep.2016.08.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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