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Article

Contractile abnormalities of mouse muscles expressing hyperkalemic periodic paralysis mutant NaV1.4 channels do not correlate with Na+ influx or channel content.

Physiological genomics - 1 Jun 2014

Lucas Brooke, Ammar Tarek, Khogali Shiemaa, DeJong Danica, Barbalinardo Michael, Nishi Cameron, Hayward Lawrence J, Renaud Jean-Marc

Abstract excerpt

Hyperkalemic periodic paralysis (HyperKPP) is characterized by myotonic discharges that occur between episodic attacks of paralysis. Individuals with HyperKPP rarely suffer respiratory distress even though diaphragm muscle expresses the same defective Na(+) channel isoform (NaV1.4) that causes symptoms in limb muscles. We tested the hypothesis that the extent of the HyperKPP phenotype (low force generation and...

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PMID: 24714718
DOI: 10.1152/physiolgenomics.00166.2013

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