Article

A new mRNA antigen vaccine induces potent B and T cell responses and <i>in vivo</i> protection against SARS-CoV-2

2026-03-03

Abstract excerpt

<h4>ABSTRACT</h4> The SARS-CoV-2 mRNA vaccine provides effective protection against viral infection and severe disease by inducing efficient adaptive immunity. However, vaccine efficacy is decreased against emerging variants, and immune memory is relatively short-lived. Here, we added new T cell epitopes to the RBD (receptor-binding domain) mRNA vaccine and identified a SARS-CoV-2 membrane epitope that significan...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fa8e11b7-23fc-5741-aa5c-ec1ef0927233
DOI: 10.64898/2026.03.02.709177

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A new mRNA antigen vaccine induces potent B and T cell responses and <i>in vivo</i> protection against SARS-CoV-2DOI 10.64898/2026.03.02.709177Read

Single cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccineSemantic proximity Read

Development of SARS-CoV-2 mRNA vaccines encoding spike N-terminal and receptor binding domainsSemantic proximity Read

Single-cell profiling of T and B cell repertoires following SARS-CoV-2 mRNA vaccineSemantic proximity Read

mRNA Vaccines: A Prospective Analysis of Long-term, Multi-target, and Autoimmune DisordersSemantic proximity Read

Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strainsSemantic proximity Read

A broad-spectrum SARS-CoV-2 RBD vaccine with selected high-impact mutations and novel adjuvant induces durable T cell response and broad protection in mice.Semantic proximity Read

Discrete Immune Response Signature to SARS-CoV-2 mRNA Vaccination Versus InfectionSemantic proximity Read

Immune gene expression analysis indicates the potential of a self-amplifying Covid-19 mRNA vaccineSemantic proximity Read

Profiling antibody epitopes induced by mRNA-1273 vaccination and boostersSemantic proximity Read

Longitudinal Analysis Reveals Distinct Antibody and Memory B Cell Responses in SARS-CoV2 Naïve and Recovered Individuals Following mRNA VaccinationSemantic proximity Read

Identification of SARS-CoV-2 Vaccine Epitopes Predicted to Induce Long-Term Population-Scale ImmunitySemantic proximity Read

Domain-based mRNA vaccines encoding spike protein N-terminal and receptor binding domains confer protection against SARS-CoV-2Semantic proximity Read