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Article

ESCRT recruitment to SARS-CoV-2 spike induces virus-like particles that improve mRNA vaccines

21 Apr 2023

Abstract excerpt

Prime-boost regimens for COVID-19 vaccines elicit poor antibody responses against Omicron-based variants and employ frequent boosters to maintain antibody levels. We present a natural infection-mimicking technology that combines features of mRNA- and protein nanoparticle-based vaccines through encoding self-assembling enveloped virus-like particles (eVLPs). eVLP assembly is achieved by inserting an ESCRT- and...

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Identifiers

PMID: 37146611
DOI: 10.1016/j.cell.2023.04.024

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