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Article

Defining tumor-associated vascular heterogeneity in pediatric high-grade and diffuse midline gliomas

23 Aug 2021

Abstract excerpt

The blood-brain barrier (BBB) plays important roles in brain tumor pathogenesis and treatment response, yet our understanding of its function and heterogeneity within or across brain tumor types remains poorly characterized. Here we analyze the neurovascular unit (NVU) of pediatric high-grade glioma (pHGG) and diffuse midline glioma (DMG) using patient derived xenografts and natively forming glioma mouse models....

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PMID: 34425907
DOI: 10.1186/s40478-021-01243-1

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