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Article

Associations between genetic variation in one-carbon metabolism and leukocyte DNA methylation in valproate-treated patients with epilepsy.

Clinical nutrition (Edinburgh, Scotland) - 1 Feb 2018

Ni Guanzhong, Qin Jiaming, Chen Ziyi, Li Hongliang, Zhou Jueqian, Huang Min, Zhou Liemin

Abstract excerpt

BACKGROUND: Valproate (VPA) as a first-line antiepileptic drug is useful for the most types of epileptic seizure treatment. Previous studies observed that VPA influenced one-carbon metabolism (OCM), consequently, DNA methylation. However, other individual genetic variations, as well as VPA, modify DNA methylation. OBJECTIVE: In this study, we investigated associations between genetic variations in OCM and...

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Source

Identifiers

PMID: 28161091
DOI: 10.1016/j.clnu.2017.01.004

Genes

MTHFR
OCM
MTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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