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Article

Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice.

Pharmacogenetics and genomics - 1 Jul 2008

Celtikci Basak, Leclerc Daniel, Lawrance Andrea K, Deng Liyuan, Friedman Hana C, Krupenko Natalia I, Krupenko Sergey A, Melnyk Stepan, James S Jill, Peterson Alan C, Rozen Rima

Abstract excerpt

OBJECTIVE: Folates provide one-carbon units for nucleotide synthesis and methylation reactions. A common polymorphism (677C-->T) in methylenetetrahydrofolate reductase (MTHFR) encodes an enzyme with reduced activity. Response to the antifolate methotrexate (MTX) may be modified in 677TT individuals because MTHFR converts nonmethylated folates, used for thymidine and purine synthesis, to 5-methyltetrahydrofolate,...

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Source

Identifiers

PMID: 18551038
DOI: 10.1097/FPC.0b013e32830058aa

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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