Article
A high frequency of the MTHFR 677C>T polymorphism in Scottish women with epilepsy: possible role in pathogenesis.
Seizure - 1 Apr 2008
Dean J C S, Robertson Z, Reid V, Wang Q, Hailey H, Moore S, Rasalam A D, Turnpenny P, Lloyd D, Shaw D, Little J
Abstract excerpt
The inheritance of most forms of epilepsy is usually considered to be multifactorial, although a number of single gene causes are known. Most previous studies of epilepsy genetics have implicated ion channel genes or ligand receptors. In a previous study of children with adverse effects of prenatal exposure to antiepileptic drugs, we noted an increased frequency of the methylene tetrahydrofolate reductase (MTHFR)...
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