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Article

Fetal anticonvulsant syndrome and mutation in the maternal MTHFR gene.

Clinical genetics - 1 Sept 1999

Dean J C, Moore S J, Osborne A, Howe J, Turnpenny P D

Abstract excerpt

Around 6% of infants born to mothers taking anticonvulsants have malformations, including neural tube defects, and a further proportion show developmental delay in later childhood. Three commonly used anticonvulsants, carbamazepine, phenytoin and sodium valproate, interfere with folic acid metabolism. We investigated the common 677 C>T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene in samples...

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Source

Identifiers

PMID: 10563481
DOI: 10.1034/j.1399-0004.1999.560306.x

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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