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Article

The Effect of APOE ε4 Allele on Dynamic Local Spontaneous Brain Activity and Functional Integration in Alzheimer's Disease.

Human brain mapping - 1 Jul 2025

Tan Yi, Yang Dan, Ke Zhihong, Hu Zheqi, Song Wenting, Tang Limoran, Zhou Zhixin, Mo Yuting, Huang Lili, Xu Yun

Abstract excerpt

The apolipoprotein E (APOE) ε4 allele is the most important genetic risk factor for sporadic Alzheimer's disease (AD), yet its mechanisms in AD pathology and cognitive decline remain unclear. Using a sliding-time window approach to directly quantify the instantaneous fluctuations of various local metrics based on continuous time series and calculate voxel-wise concordance of these metrics, we explored the impact...

Read the complete abstract on PubMed

Topics

Humans
Alzheimer Disease
Apolipoprotein E4
Male
Female
Aged
Magnetic Resonance Imaging

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Amyloid beta-Peptides

Alleles

Aged, 80 and over

Brain

Source

Open in PubMed Open full text

Identifiers

PMID: 40642909
DOI: 10.1002/hbm.70269
PMCID: PMC12246834

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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