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Article

Altered spontaneous brain activity pattern in cognitively normal young adults carrying mutations of APP, presenilin-1/2 and APOE ε4.

European journal of radiology - 1 Oct 2017

Zheng Li Juan, Su Yun Yan, Wang Yun Fei, Zhong Jianhui, Liang Xue, Zheng Gang, Lu Guang Ming, Zhang Long Jiang

Abstract excerpt

OBJECTIVE: To explore genetic effects of amyloid precursor protein (APP), presenilin-1/2 and apolipoprotein E (APOE) ε4 on brain structural and functional alterations in cognitively normal young adults. MATERIALS AND METHODS: Eighty healthy adults (mean age 24.0±2.5years; n=18, APP/presenilin-1/2 group; n=31, APOE ε4 group; n=31, control group [without above-mentioned gene mutation]) underwent high-resolution...

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Identifiers

PMID: 28987665
DOI: 10.1016/j.ejrad.2017.07.006

Genes

APOE
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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