Article

Cell type mapping of mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy using single-nucleus multiomics

2024-12-12

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) are brain lesions associated with focal epilepsy and characterized by increased oligodendroglial density, heterotopic neurons, and hypomyelination in the white matter. While previous studies have implicated somatic mutations in the SLC35A2 gene, the cellular and molecular mechani...

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Literature Corpus work: 6d8a4119-d9af-5739-9f9d-cd57d238a35a
DOI: 10.1101/2024.12.12.628140

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