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Endothelial plasticity in atrial fibrosis by integrating single-cell sequencing and genetic lineage tracing

21 May 2025

Abstract excerpt

BACKGROUND AND AIMS: Atrial fibrosis represents a critical determinant in atrial fibrillation (AF) pathogenesis. Although endothelial dysfunction is a hallmark feature of AF, the precise mechanisms by which endothelial cells (ECs) contribute to atrial fibrosis remain incompletely understood. METHODS: This study employed single-cell RNA sequencing (scRNA-seq) to analyze intercellular communication networks in...

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PMID: 40626706
DOI: 10.1093/eurheartj/ehaf372

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