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Article

Affinity purification of cell-specific mitochondria from whole animals resolves patterns of genetic mosaicism.

Nature cell biology - 1 Mar 2018

Ahier Arnaud, Dai Chuan-Yang, Tweedie Andrea, Bezawork-Geleta Ayenachew, Kirmes Ina, Zuryn Steven

Abstract excerpt

Although mitochondria are ubiquitous organelles, they exhibit tissue-specific morphology, dynamics and function. Here, we describe a robust approach to isolate mitochondria from specific cells of diverse tissue systems in Caenorhabditis elegans. Cell-specific mitochondrial affinity purification (CS-MAP) yields intact and functional mitochondria with exceptional purity and sensitivity (>96% enrichment, >96%...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29358705
DOI: 10.1038/s41556-017-0023-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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