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Article

The antiport mechanism of the human LAT1 transporter: defining the molecular determinants by means of wet and dry approaches.

Biochemical and biophysical research communications - 1 Sept 2025

Scalise Mariafrancesca, Scanga Raffaella, Console Lara, Galluccio Michele, Indiveri Cesare

Abstract excerpt

LAT1 (SLC7A5) catalyzes an antiport of essential amino acids at the Blood Brain Barrier and placenta barrier where it is mainly expressed. LAT1 becomes overexpressed in human cancers, even when originating from tissues in which it is not highly expressed. The antiport mediated by the transporter is crucial for maintaining the essential amino acid homeostasis in the brain, as demonstrated by the occurrence of...

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Identifiers

PMID: 40616981
DOI: 10.1016/j.bbrc.2025.152277

Genes

SLC7A5

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