Article
A Call for Systematic Research on Solute Carriers.
Cell - 30 Jul 2015
César-Razquin Adrián, Snijder Berend, Frappier-Brinton Tristan, Isserlin Ruth, Gyimesi Gergely, Bai Xiaoyun, Reithmeier Reinhart A, Hepworth David, Hediger Matthias A, Edwards Aled M, Superti-Furga Giulio
Abstract excerpt
Solute carrier (SLC) membrane transport proteins control essential physiological functions, including nutrient uptake, ion transport, and waste removal. SLCs interact with several important drugs, and a quarter of the more than 400 SLC genes are associated with human diseases. Yet, compared to other gene families of similar stature, SLCs are relatively understudied. The time is right for a systematic attack on...
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