Article

Divergent metabolomic signatures by LAT1 and LAT2 amino acid transporters and characterization of biased LAT1 inhibitors and mutations

2023-07-31

Abstract excerpt

<h4>Background: </h4> and Purpose L-type amino acid (AA) transporters LAT1 (SLC7A5) and LAT2 (SLC7A8) facilitate the bidirectional transport of branched and aromatic AA across the plasma membrane. While LAT1 is overexpressed in different tumour cells and it is dedicated to deliver AA into growing cells, LAT2 facilitates the transcellular AA transport at biological barriers. Data on dynamic AA transport by LAT1/2 i...

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Literature Corpus work: ad8c62f1-3276-5af3-b2f8-ad5a6eeb1bd9
DOI: 10.22541/au.169078529.90280955/v1

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