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MTHFD1L, A Folate Cycle Enzyme, Is Involved in Progression of Colorectal Cancer

14 Aug 2019

Abstract excerpt

Identification of new molecular targets is needed for the treatment of colorectal cancer (CRC). Methylenetetrahydrofolate dehydrogenase 1 like (MTHFD1L), an enzyme in the folate cycle, is involved in formate generation and therefore in one-carbon metabolism. Here, we examined the expression and the role of MTHFD1L in CRC progression. Bioinformatics analysis of several public databases showed overexpression of...

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PMID: 31421459
DOI: 10.1016/j.tranon.2019.07.011

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