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Article

Involvement of KEAP1/NRF2 pathway in non-BRAF mutated squamous cell carcinoma of the thyroid.

The Journal of pathology - 1 Aug 2025

Schoultz Elin, Dahlberg Jakob, Nilsson Lisa M, Dzanan Jozefina J, Carlsson Therese, Dahr Niklas, Andersson Ellinor, Muhammad Ghayeb, Muth Andreas, Elias Erik, Fagman Henrik, Sayin Volkan I, Nilsson Jonas A, Nilsson Mikael

Abstract excerpt

Squamous cell carcinoma (SCC) of the thyroid is a rare tumor that is classified as an anaplastic thyroid cancer (ATC) due to its similar unresponsiveness to chemoradiotherapy and an outstandingly poor prognosis. Due to its rarity, current knowledge about this tumor is mostly based on single-case reports. The tumor-cell-origin and molecular pathogenesis remain unclear, although the presence of BRAF mutations in...

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Source

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Identifiers

PMID: 40600748
DOI: 10.1002/path.6444
PMCID: PMC12256384

Genes

KEAP1
BRAF
CDH2
CDKN2A
NFE2L2
NOG
NQO1
PIK3CA
RB1
SNAI2
STK11
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Involvement of KEAP1/NRF2 pathway in non-BRAF mutated squamous cell carcinoma of the thyroid.PMID 40600748Read ↗

<i>KEAP1</i> mutations activate the NRF2 pathway to drive cell growth and migration, and attenuate drug response in thyroid cancerSemantic proximity Read ↗

Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer.Semantic proximity Read ↗

Convergent Mechanistic Pathways Driving the Anaplastic Phenotype in Thyroid Cancer.Semantic proximity Read ↗

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SIRT7 promotes the proliferation and migration of anaplastic thyroid cancer cells by regulating the desuccinylation of KIF23Semantic proximity Read ↗

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