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Article

KSR1 is coordinately regulated with Notch signaling and oxidative phosphorylation in thyroid cancer.

Journal of molecular endocrinology - 1 Apr 2015

Lee Jandee, Seol Mi-Youn, Jeong Seonhyang, Kwon Hyeong Ju, Lee Cho Rok, Ku Cheol Ryong, Kang Sang-Wook, Jeong Jong Ju, Shin Dong Yeob, Nam Kee-Hyun, Lee Eun Jig, Chung Woong Youn, Jo Young Suk

Abstract excerpt

Kinase suppressor of RAS1 (KSR1) is a scaffold protein implicated in RAS-mediated RAF activation. However, the molecular function of KSR in papillary thyroid cancer (PTC) is unknown. Thus, this study aimed to characterize the role of KSR1 in patients with PTC. qRT-PCR and immunohistochemistry (IHC) revealed inter-tumor heterogeneities in the expression of KSR1 in PTC tissues. Interestingly, BRAFV600E-positive PTC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oxidative Phosphorylation

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Share to Receptors, Notch

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Source

Identifiers

PMID: 25608512
DOI: 10.1530/JME-14-0270

Genes

KSR1
KSR2
NOTCH1
HES1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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