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Article

BRAFV600E/p-ERK/p-DRP1(Ser616) Promotes Tumor Progression and Reprogramming of Glucose Metabolism in Papillary Thyroid Cancer.

Thyroid : official journal of the American Thyroid Association - 1 Oct 2024

Wen Shi-Shuai, Wu Yi-Jun, Wang Jia-Yang, Ni Zhao-Xian, Dong Shuai, Xie Xiao-Jun, Wang Yu-Ting, Wang Yu, Huang Nai-Si, Ji Qing-Hai, Ma Ben, Qu Ning

Abstract excerpt

Background: Papillary thyroid cancer (PTC) with the BRAFV600E mutation is associated with a poorer prognosis. BRAF inhibitors may demonstrate limited efficacy due to emerging drug resistance. The Warburg effect may have cancer therapeutic implications. It is not known if the BRAFV600E mutation is associated with altered glucose metabolism in PTC. Methods: This study examined the effect of BRAFV600E and...

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Identifiers

PMID: 39162997
DOI: 10.1089/thy.2023.0700

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