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Article

Macrophages from the synovium of active rheumatoid arthritis exhibit an activin A-dependent pro-inflammatory profile.

The Journal of pathology - 1 Feb 2015

Soler Palacios Blanca, Estrada-Capetillo Lizbeth, Izquierdo Elena, Criado Gabriel, Nieto Concha, Municio Cristina, González-Alvaro Isidoro, Sánchez-Mateos Paloma, Pablos Jose Luis, Corbí Angel L, Puig-Kröger Amaya

Abstract excerpt

Rheumatoid arthritis (RA) is a chronic inflammatory disease whose pathogenesis and severity correlates with the presence of macrophage-derived pro-inflammatory cytokines within the inflamed synovium. Macrophage-derived cytokines fuel the pathological processes in RA and are targets of clinically successful therapies. However, although macrophage polarization determines cytokine production, the polarization state...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25319955
DOI: 10.1002/path.4466

Genes

CCR2
EGLN3
MMP12
IGF1
FOLR2
INHBA
SERPINB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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