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Article

Semaphorin3B promotes an anti-inflammatory and pro-resolving phenotype in macrophages from rheumatoid arthritis patients in a MerTK-dependent manner.

Frontiers in immunology - 1 Jan 2023

Martínez-Ramos Sara, Rafael-Vidal Carlos, Malvar-Fernández Beatriz, Pérez Nair, Mouriño Coral, Pérez Sara García, Maceiras Pan Francisco J, Conde Carmen, Pego-Reigosa Jose María, García Samuel

Abstract excerpt

Previous works from our group show that Semaphorin3B (Sema3B) is reduced in RA and plays a protective role in a mouse arthritis model. In turn, MerTK plays a protective function in murine arthritis models, is expressed by synovial tissue macrophages and is linked to remission in patients with RA. In this study, we examined the role of Sema3B in the phenotypic characteristics of RA macrophages and the implication...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38283352
DOI: 10.3389/fimmu.2023.1268144
PMCID: PMC10811190

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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