Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ATF7 – PINK1 Axis Governs Mitophagy and Intestinal Inflammation in Ulcerative Colitis

30 Jun 2025

Abstract excerpt

Ulcerative colitis (UC), a chronic inflammatory bowel disease, is marked by sustained inflammation and excessive apoptosis of intestinal epithelial cells (IECs). Despite progress in understanding UC pathogenesis, the role of activating transcription factors (ATFs) in disease progression remains elusive. Here, we profile the expression of ATF family members (ATF1-ATF7) in the colonic mucosa of UC patients and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine and Purinergic Signaling
Share to Autophagy in Disease and Therapy
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40586859
DOI: 10.1096/fj.202500813r

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ATF7 – PINK1 Axis Governs Mitophagy and Intestinal Inflammation in Ulcerative ColitisPMID 40586859Read ↗

Identification of differentially expressed genes associated with ferroptosis in ulcerative colitisSemantic proximity Read ↗

An ATF4-centric regulatory network is required for the assembly and function of the OXPHOS systemSemantic proximity Read ↗

ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt PathwaySemantic proximity Read ↗

QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasisSemantic proximity Read ↗

β-arrestin1 protects intestinal tight junction through promoting mitofusin 2 transcription to drive parkin-dependent mitophagy in colitisSemantic proximity Read ↗

ATF 3 represses PINK 1 gene transcription in lung epithelial cells to control mitochondrial homeostasisSemantic proximity Read ↗

Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to Promote Colorectal TumorigenesisSemantic proximity Read ↗

GATA6-AS1 Regulates Intestinal Epithelial Mitochondrial Functions, and its Reduced Expression is Linked to Intestinal Inflammation and Less Favourable Disease Course in Ulcerative ColitisSemantic proximity Read ↗

ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic ReticulumSemantic proximity Read ↗

Dysregulated phosphatidylinositol signaling promotes endoplasmic-reticulum-stress-mediated intestinal mucosal injury and inflammation in zebrafish.Semantic proximity Read ↗

Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal HealingSemantic proximity Read ↗

The transcription factor ATF4 mediates endoplasmic reticulum stress-related podocyte injury and slit diaphragm defectsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.