Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ATF 3 represses PINK 1 gene transcription in lung epithelial cells to control mitochondrial homeostasis

24 Jan 2018

Abstract excerpt

PINK1 (PTEN-induced putative kinase 1) is a key regulator of mitochondrial homeostasis that is relatively depleted in aging lungs and in lung epithelial cells from patients with idiopathic pulmonary fibrosis (IPF), a disease linked with aging. Impaired PINK1 expression and accumulation of damaged mitochondria in lung epithelial cells from fibrotic lungs were associated with the presence of ER stress. Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Share to Neonatal Respiratory Health Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29363258
DOI: 10.1111/acel.12720

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ATF 3 represses PINK 1 gene transcription in lung epithelial cells to control mitochondrial homeostasisPMID 29363258Read ↗

PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosisSemantic proximity Read ↗

The Dual Roles of Activating Transcription Factor 3 (ATF3) in Inflammation, Apoptosis, Ferroptosis, and Pathogen Infection ResponsesSemantic proximity Read ↗

ATF3 Regulates the Stability of p53: A Link to CancerSemantic proximity Read ↗

Cell-type-specific ATF6α programs regulate epithelial mitochondrial homeostasis and pericyte remodeling during physiological and exposure-accelerated lung agingSemantic proximity Read ↗

Master Regulator Activating Transcription Factor 3 (ATF3) in Metabolic Homeostasis and CancerSemantic proximity Read ↗

PINK1 attenuates mtDNA release in alveolar epithelial cells and TLR9 mediated profibrotic responsesSemantic proximity Read ↗

Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination.Semantic proximity Read ↗

ATF7 – PINK1 Axis Governs Mitophagy and Intestinal Inflammation in Ulcerative ColitisSemantic proximity Read ↗

Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stressSemantic proximity Read ↗

An ATF4-centric regulatory network is required for the assembly and function of the OXPHOS systemSemantic proximity Read ↗

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals.Semantic proximity Read ↗

The transcription factor ATF3 switches cell death from apoptosis to necroptosis in hepatic steatosis in male miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.