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Article

Understanding Interactions Between Life Satisfaction and Genetic Predisposition on Risk of Alzheimer's Disease up to 14 Years Later: Findings From the UK Biobank.

International journal of geriatric psychiatry - 1 Jul 2025

John Amber, Desai Roopal, Bartres-Faz David, Cadar Dorina, Gaysina Darya, Gonzalez Aida Suarez, Marchant Natalie L, Willroth Emily, Richards Marcus, Saunders Rob, Stott Joshua

Abstract excerpt

OBJECTIVES: Previous research investigating associations between life satisfaction and risk of Alzheimer's disease (AD) has been mixed. This association may differ depending on genetic risk for AD. The aim of this study was to test interactions between life satisfaction and genetic predisposition on the future incidence of AD diagnosis. METHODS: Data were used from 66,668 participants aged 60+ from the UK...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40581914
DOI: 10.1002/gps.70120
PMCID: PMC12206470

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